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Acetazolamide serves as selective delivery vehicle for dipeptide-linked drugs to renal cell carcinoma

In most cases, cytotoxic drugs do not preferentially accumulate at the tumor site, causing unwanted toxicities and preventing dose escalation to therapeutically active regimens. Here, we show that acetazolamide derivatives, which bind to carbonic anhydrase IX (CAIX) on the surface of kidney cancer c...

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Publicat a:Mol Cancer Ther
Autors principals: Cazzamalli, Samuele, Dal Corso, Alberto, Neri, Dario
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214883/
https://ncbi.nlm.nih.gov/pubmed/27609641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0283
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