SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis

Fas-associated protein with death domain (FADD) plays a key role in extrinsic apoptosis. Here, we show that FADD is SUMOylated as an essential step during intrinsic necrosis. FADD was modified at multiple lysine residues (K120/125/149) by small ubiquitin-related modifier 2 (SUMO2) during necrosis ca...

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Udgivet i:Mol Cell Biol
Main Authors: Choi, Seon-Guk, Kim, Hyunjoo, Jeong, Eun Il, Lee, Ho-June, Park, Sungwoo, Lee, Song-Yi, Lee, Hyeon-Jeong, Lee, Seong Won, Chung, Chin Ha, Jung, Yong-Keun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214857/
https://ncbi.nlm.nih.gov/pubmed/27799292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00254-16
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