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Choline dehydrogenase interacts with SQSTM1/p62 to recruit LC3 and stimulate mitophagy
CHDH (choline dehydrogenase) is an enzyme catalyzing the dehydrogenation of choline to betaine aldehyde in mitochondria. Apart from this well-known activity, we report here a pivotal role of CHDH in mitophagy. Knockdown of CHDH expression impairs CCCP-induced mitophagy and PARK2/parkin-mediated clea...
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| Publicado no: | Autophagy |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4502719/ https://ncbi.nlm.nih.gov/pubmed/25483962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.32177 |
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