All four known cyclic adducts formed in DNA by the vinyl chloride metabolite chloroacetaldehyde are released by a human DNA glycosylase.

We have previously reported that human cells and tissues contain a 1,N6-ethenoadenine (epsilon A) binding protein, which, through glycosylase activity, releases both 3-methyladenine (m3A) and epsilon A from DNA treated with methylating agents or the vinyl chloride metabolite chloroacetaldehyde, resp...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Dosanjh, M K, Chenna, A, Kim, E, Fraenkel-Conrat, H, Samson, L, Singer, B
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC521446/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8302827/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.3.1024
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