Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury

Mitochondrial dysfunction underlies many prevalent diseases including heart disease arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy, which selectively removes damaged or unwanted mitochondria, regulated mitochondrial quality and quantity in vivo. Hypoxia ind...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Zhang, Weilin, Ren, He, Xu, Chunling, Zhu, Chongzhuo, Wu, Hao, Liu, Dong, Wang, Jun, Liu, Lei, Li, Wei, Ma, Qi, Du, Lei, Zheng, Ming, Zhang, Chuanmao, Liu, Junling, Chen, Quan
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2016
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214169/
https://ncbi.nlm.nih.gov/pubmed/27995894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21407
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