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Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway

Platelets undergo apoptosis in response to a variety of stimuli in the circulation. Mitochondria in platelets are essential for their apoptosis. Specifically, pro-survival protein BCL-x(L) on mitochondria is the key regulator of platelet lifespan. Here we identify an outer mitochondrial membrane pro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Death Differ
Prif Awduron: Ma, Qi, Zhu, Chongzhuo, Zhang, Weilin, Ta, Na, Zhang, Rong, Liu, Lei, Feng, Du, Cheng, Heping, Liu, Junling, Chen, Quan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329745/
https://ncbi.nlm.nih.gov/pubmed/29786068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0121-8
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