The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas

Tryptophan metabolism is a key process that shapes the immunosuppressive tumor microenvironment. The two rate-limiting enzymes that mediate tryptophan depletion, indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO), have moved into the focus of research and inhibitors targeting IDO...

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Publicado en:Oncoimmunology
Autores principales: Sonner, Jana K., Deumelandt, Katrin, Ott, Martina, Thomé, Carina M., Rauschenbach, Katharina J., Schulz, Sandra, Munteanu, Bogdan, Mohapatra, Soumya, Adam, Isabell, Hofer, Ann-Cathrin, Feuerer, Markus, Opitz, Christiane A., Hopf, Carsten, Wick, Wolfgang, Platten, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214097/
https://ncbi.nlm.nih.gov/pubmed/28123877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1240858
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