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Single-nucleotide polymorphism discovery by targeted DNA photocleavage

Single-nucleotide polymorphisms are the largest source of genetic variation in humans. We report a method for the discovery of single-nucleotide polymorphisms within genomic DNA. Pooled genomic samples are amplified, denatured, and annealed to generate mismatches at polymorphic DNA sites. Upon photo...

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Bibliografiska uppgifter
Huvudupphovsmän: Hart, Jonathan R., Johnson, Martin D., Barton, Jacqueline K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC521117/
https://ncbi.nlm.nih.gov/pubmed/15383659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406169101
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