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Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA
The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC165857/ https://ncbi.nlm.nih.gov/pubmed/12777616 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1237858100 |
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