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Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA

The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yang, Yaning, Zhang, Jingshan, Hoh, Josephine, Matsuda, Fumihiko, Xu, Peng, Lathrop, Mark, Ott, Jurg
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165857/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12777616/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1237858100
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