Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA

The efficiency of single-nucleotide polymorphism haplotype analysis may be increased by DNA pooling, which can dramatically reduce the number of genotyping assays. We develop a method for obtaining maximum likelihood estimates of haplotype frequencies for different pool sizes, assess the accuracy of...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Yang, Yaning, Zhang, Jingshan, Hoh, Josephine, Matsuda, Fumihiko, Xu, Peng, Lathrop, Mark, Ott, Jurg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2003
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165857/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12777616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1237858100
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