Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers

BACKGROUND: Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total treatment...

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Publicat a:BMC Bioinformatics
Autors principals: Hofmann, Ariane L., Behr, Jonas, Singer, Jochen, Kuipers, Jack, Beisel, Christian, Schraml, Peter, Moch, Holger, Beerenwinkel, Niko
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209852/
https://ncbi.nlm.nih.gov/pubmed/28049408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1417-7
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