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Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis

Two nerve cells types, Betz cells in layer Vb of the primary motor neocortex and α-motoneurons of the lower brainstem and spinal cord, become involved at the beginning of the pathological cascade underlying sporadic amyotrophic lateral sclerosis (sALS). In both neuronal types, the cell nuclei forfei...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Braak, Heiko, Ludolph, Albert C., Neumann, Manuela, Ravits, John, Del Tredici, Kelly
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5209403/
https://ncbi.nlm.nih.gov/pubmed/27757524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-016-1633-2
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