TDP-43 Is Not a Common Cause of Sporadic Amyotrophic Lateral Sclerosis

BACKGROUND: TAR DNA binding protein, encoded by TARDBP, was shown to be a central component of ubiquitin-positive, tau-negative inclusions in frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Recently, mutations in TARDBP have been linked to familial and sporadic AL...

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Detalhes bibliográficos
Main Authors: Guerreiro, Rita J., Schymick, Jennifer C., Crews, Cynthia, Singleton, Andrew, Hardy, John, Traynor, Bryan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2408729/
https://ncbi.nlm.nih.gov/pubmed/18545701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002450
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