The Role of Age on Dose Limiting Toxicities (DLTs) in Phase I Dose-escalation Trials

PURPOSE: Elderly oncology patients are not enrolled in early phase trials in proportion to the numbers of geriatric patients with cancer. There may be concern that elderly patients will not tolerate investigational agents as well as younger patients resulting in a disproportionate number of dose-lim...

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Pubblicato in:Clin Cancer Res
Autori principali: Schwandt, A, Harris, P. J., Hunsberger, S., Deleporte, A., Smith, G. L., Vulih, D., Anderson, B. D., Ivy, S. P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207798/
https://ncbi.nlm.nih.gov/pubmed/25028396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0866
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