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Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes.

The purposes of this study were to elucidate the effects of recombinant human interleukin 7 (rhIL-7) on proliferation as well as differentiation of human fetal thymocytes and to analyze the biochemical nature of the IL-7 receptor-linked transmembrane signal. In the absence of costimulants, rhIL-7 st...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Uckun, F M, Tuel-Ahlgren, L, Obuz, V, Smith, R, Dibirdik, I, Hanson, M, Langlie, M C, Ledbetter, J A
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1991
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52075/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2068112/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.14.6323
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