Enhancement of IUdR Radiosensitization by Low-Energy Photons Results from Increased and Persistent DNA Damage

Low-energy X-rays induce Auger cascades by photoelectric absorption in iodine present in the DNA of cells labeled with 5-iodo-2’-deoxyuridine (IUdR). This photoactivation therapy results in enhanced cellular sensitivity to radiation which reaches its maximum with 50 keV photons. Synchrotron core fac...

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Vydáno v:PLoS One
Hlavní autoři: Bayart, Emilie, Pouzoulet, Frédéric, Calmels, Lucie, Dadoun, Jonathan, Allot, Fabien, Plagnard, Johann, Ravanat, Jean-Luc, Bridier, André, Denozière, Marc, Bourhis, Jean, Deutsch, Eric
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207426/
https://ncbi.nlm.nih.gov/pubmed/28045991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168395
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