Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers

Over the last 7 years, we have focused our experimental and computational research efforts on improving our understanding of the biochemical, molecular, and cellular processing of iododeoxyuridine (IUdR) and ionizing radiation (IR) induced DNA base damage by DNA mismatch repair (MMR). These coordina...

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Detalhes bibliográficos
Main Authors: Kinsella, Timothy J., Gurkan-Cavusoglu, Evren, Du, Weinan, Loparo, Kenneth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355906/
https://ncbi.nlm.nih.gov/pubmed/22649757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2011.00020
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