The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Although tumor-specific T cells recognize cancer cells, they are often rendered dysfunctional due to an immunosuppressive microenvironment. Here we showed that T cells demonstrated persistent loss of mitochondrial function and mass when infiltrating murine and human tumors, an effect specific to the...

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Publicado en:Immunity
Autores principales: Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207350/
https://ncbi.nlm.nih.gov/pubmed/27496732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.009
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