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Enantioselective Pd-Catalyzed Allylic Alkylation Reactions of Dihydropyrido[1,2-a]indolone Substrates: Efficient Syntheses of (−)-Goniomitine, (+)-Aspidospermidine, and (−)-Quebrachamine

The successful application of dihydropyrido[1,2-a]indolone (DHPI) substrates in Pd-catalyzed asymmetric allylic alkylation chemistry facilitates rapid access to multiple alkaloid frameworks in an enantioselective fashion. Strategic bromination at the indole C3 position greatly improved the allylic a...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Pritchett, Beau P., Kikuchi, Jun, Numajiri, Yoshitaka, Stoltz, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207349/
https://ncbi.nlm.nih.gov/pubmed/27666731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201608138
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