Potent and Selective Peptide-based Inhibition of the G Protein Gα(q)

In contrast to G protein-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few compounds are available that directly modulate heterotrimeric G proteins. Active Gα(q) binds its two major classes of effectors, the phospholipase C (PLC)-β isozymes and Rho gua...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Charpentier, Thomas H., Waldo, Gary L., Lowery-Gionta, Emily G., Krajewski, Krzysztof, Strahl, Brian D., Kash, Thomas L., Harden, T. Kendall, Sondek, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Methods and Resources
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207258/
https://ncbi.nlm.nih.gov/pubmed/27742837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740407
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