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Potent and Selective Peptide-based Inhibition of the G Protein Gα(q)
In contrast to G protein-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few compounds are available that directly modulate heterotrimeric G proteins. Active Gα(q) binds its two major classes of effectors, the phospholipase C (PLC)-β isozymes and Rho gua...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207258/ https://ncbi.nlm.nih.gov/pubmed/27742837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.740407 |
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