Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression

A large percentage of redox-responsive gene promoters contain evolutionarily conserved guanine-rich clusters; guanines are the bases most susceptible to oxidative modification(s). Consequently, 7,8-dihydro-8-oxoguanine (8-oxoG) is one of the most abundant base lesions in promoters and is primarily r...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Pan, Lang, Zhu, Bing, Hao, Wenjing, Zeng, Xianlu, Vlahopoulos, Spiros A., Hazra, Tapas K., Hegde, Muralidhar L., Radak, Zsolt, Bacsi, Attila, Brasier, Allan R., Ba, Xueqing, Boldogh, Istvan
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Gene Regulation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207254/
https://ncbi.nlm.nih.gov/pubmed/27756845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751453
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