Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium

Accumulation of bis-retinoids in the retinal pigmented epithelium (RPE) is a hallmark of aging and retinal disorders such as Stargardt disease and age-related macular degeneration. These aberrant fluorescent condensation products, including di-retinoid-pyridinium-ethanolamine (A2E), are thought to b...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Palczewska, Grazyna, Maeda, Akiko, Golczak, Marcin, Arai, Eisuke, Dong, Zhiqian, Perusek, Lindsay, Kevany, Brian, Palczewski, Krzysztof
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207201/
https://ncbi.nlm.nih.gov/pubmed/27875314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764563
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