RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE?

Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arth...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Johnson, Zariel I., Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207178/
https://ncbi.nlm.nih.gov/pubmed/27875309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757732
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