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RNA Sequencing Reveals a Role of TonEBP Transcription Factor in Regulation of Pro-inflammatory Genes in Response to Hyperosmolarity in Healthy Nucleus Pulposus Cells: A HOMEOSTATIC RESPONSE?

Transcription factor tonicity-responsive enhancer-binding protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arth...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Johnson, Zariel I., Shapiro, Irving M., Risbud, Makarand V.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207178/
https://ncbi.nlm.nih.gov/pubmed/27875309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.757732
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