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Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange
Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site. We have used a fragment-based approach on malate synthase (GlcB) from Mycobacterium tuberculosis and discovered several novel bind...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207166/ https://ncbi.nlm.nih.gov/pubmed/27738104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750877 |
| Oznake: |
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