Structure-guided Discovery of Phenyl diketo-acids as Potent Inhibitors of M. tuberculosis Malate Synthase

The glyoxylate shunt plays an important role in fatty-acid metabolism, and has been shown to be critical to survival of several pathogens involved in chronic infections. For Mycobacterium tuberculosis (Mtb), a strain with a defective glyoxylate shunt was previously shown to be unable to establish in...

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Autori principali: Krieger, Inna V., Freundlich, Joel S., Gawandi, Vijay B., Roberts, Justin P., Gawandi, Vidyadhar B., Sun, Qingan, Owen, Joshua L., Fraile, Maria T., Huss, Sofia I., Lavandera, Jose-Luis, Ioerger, Thomas R., Sacchettini, James C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530165/
https://ncbi.nlm.nih.gov/pubmed/23261599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.018
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