Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange

Fragment screening and high throughput screening are complementary approaches that combine with structural biology to explore the binding capabilities of an active site. We have used a fragment-based approach on malate synthase (GlcB) from Mycobacterium tuberculosis and discovered several novel bind...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Huang, Hsiao-Ling, Krieger, Inna V., Parai, Maloy K., Gawandi, Vijay B., Sacchettini, James C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Protein Structure and Folding
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207166/
https://ncbi.nlm.nih.gov/pubmed/27738104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750877
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