Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias

There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative “Escape from X-Inactivation Tumor Suppressor” (EXITS)...

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Udgivet i:Nat Genet
Main Authors: Dunford, Andrew, Weinstock, David M., Savova, Virginia, Schumacher, Steven E., Cleary, John P., Yoda, Akinori, Sullivan, Timothy J., Hess, Julian M., Gimelbrant, Alexander A., Beroukhim, Rameen, Lawrence, Michael S., Getz, Gad, Lane, Andrew A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206905/
https://ncbi.nlm.nih.gov/pubmed/27869828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3726
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