Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias

There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative “Escape from X-Inactivation Tumor Suppressor” (EXITS)...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Dunford, Andrew, Weinstock, David M., Savova, Virginia, Schumacher, Steven E., Cleary, John P., Yoda, Akinori, Sullivan, Timothy J., Hess, Julian M., Gimelbrant, Alexander A., Beroukhim, Rameen, Lawrence, Michael S., Getz, Gad, Lane, Andrew A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206905/
https://ncbi.nlm.nih.gov/pubmed/27869828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3726
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