A Genetically Encoded Allysine for the Synthesis of Proteins with Site-specific Lysine Dimethylation

Using the amber suppression approach, N(ε)-(4-azidobenzoxycarbonyl)-δ, ε-dehydrolysine, an allysine precursor is genetically encoded in E. coli. Its genetic incorporation followed by two sequential biocompatible reactions allows convenient synthesis of proteins with site-specific lysine dimethylatio...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Wang, Zhipeng A., Zeng, Yu, Kurra, Yadagiri, Wang, Xin, Tharp, Jeffrey M., Vatansever, Erol C., Hsu, Willie W., Dai, Susie, Fang, Xinqiang, Liu, Wenshe R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206893/
https://ncbi.nlm.nih.gov/pubmed/27910233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201609452
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