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LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis
Leucine Rich Repeat Containing 8A (LRRC8A) is a required component of volume-regulated anion channels (VRACs). In vascular smooth muscle cells, tumor necrosis factor-α (TNFα) activates VRAC via type 1 TNFα receptors (TNFR1), and this requires superoxide (O(2)(•−)) production by NADPH oxidase 1 (Nox1...
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| Publicado no: | Free Radic Biol Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206799/ https://ncbi.nlm.nih.gov/pubmed/27838438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2016.11.003 |
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