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Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice

Aim: The treatment of psoriasis remains elusive, underscoring the need for identifying novel disease targets and mechanism-based therapeutic approaches. We recently reported that the PI3K/Akt/mTOR pathway that is frequently deregulated in many malignancies is also clinically relevant for psoriasis....

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Bibliografiske detaljer
Udgivet i:Antioxid Redox Signal
Main Authors: Chamcheu, Jean Christopher, Adhami, Vaqar M., Esnault, Stephane, Sechi, Mario, Siddiqui, Imtiaz A., Satyshur, Kenneth A., Syed, Deeba N., Dodwad, Shah-Jahan M., Chaves-Rodriquez, Maria-Ines, Longley, B. Jack, Wood, Gary S., Mukhtar, Hasan
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206770/
https://ncbi.nlm.nih.gov/pubmed/27393705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6769
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