The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies. In the hemat...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lemonnier, François, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Dupuy, Aurélie, Broutin, Sophie, Martin, Nadine, Fataccioli, Virginie, Pelletier, Romain, Wakeham, Andrew, Snow, Bryan E., de Leval, Laurence, Pujals, Anais, Haioun, Corinne, Paci, Angelo, Tobin, Erica R., Narayanaswamy, Rohini, Yen, Katherine, Jin, Shengfang, Gaulard, Philippe, Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206549/
https://ncbi.nlm.nih.gov/pubmed/27956631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617929114
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