The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development

Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the development of a number of malignancies. In the hemat...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Lemonnier, François, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Dupuy, Aurélie, Broutin, Sophie, Martin, Nadine, Fataccioli, Virginie, Pelletier, Romain, Wakeham, Andrew, Snow, Bryan E., de Leval, Laurence, Pujals, Anais, Haioun, Corinne, Paci, Angelo, Tobin, Erica R., Narayanaswamy, Rohini, Yen, Katherine, Jin, Shengfang, Gaulard, Philippe, Mak, Tak W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206549/
https://ncbi.nlm.nih.gov/pubmed/27956631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617929114
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars