Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice

Gain-of-function mutations in isocitrate dehydrogenase 1 (IDH1) are key drivers of hematopoietic malignancies. Although these mutations are most commonly associated with myeloid diseases, they also occur in malignancies of the T-cell lineage. To investigate their role in these diseases and provide t...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hao, Zhenyue, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Sheng, Yi, Lemonnier, François, Wakeham, Andrew, Snow, Bryan E., Dominguez-Brauer, Carmen, Ye, Jing, Larsen, Dana M., Straley, Kimberly S., Tobin, Erica R., Narayanaswamy, Rohini, Gaulard, Philippe, Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747700/
https://ncbi.nlm.nih.gov/pubmed/26787889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1525354113
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