Mutant IDH is sufficient to initiate enchondromatosis in mice

Enchondromas are benign cartilage tumors and precursors to malignant chondrosarcomas. Somatic mutations in the isocitrate dehydrogenase genes (IDH1 and IDH2) are present in the majority of these tumor types. How these mutations cause enchondromas is unclear. Here, we identified the spectrum of IDH m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Hirata, Makoto, Sasaki, Masato, Cairns, Rob A., Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y., Snow, Bryan E., Jones, Lisa D., Wei, Qingxia, Sato, Shingo, Tang, Yuning J., Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W., Alman, Benjamin A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352794/
https://ncbi.nlm.nih.gov/pubmed/25730874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424400112
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