CRISPR screen identifies the NCOR/HDAC3 complex as a major suppressor of differentiation in rhabdomyosarcoma

Dysregulated gene expression resulting from abnormal epigenetic alterations including histone acetylation and deacetylation has been demonstrated to play an important role in driving tumor growth and progression. However, the mechanisms by which specific histone deacetylases (HDACs) regulate differe...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Phelps, Michael P., Bailey, Jenna N., Vleeshouwer-Neumann, Terra, Chen, Eleanor Y.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206534/
https://ncbi.nlm.nih.gov/pubmed/27956629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610270114
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