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Active-site MMP-selective antibody inhibitors discovered from convex paratope synthetic libraries
Proteases are frequent pharmacological targets, and their inhibitors are valuable drugs in multiple pathologies. The catalytic mechanism and the active-site fold, however, are largely conserved among the protease classes, making the development of the selective inhibitors exceedingly challenging. In...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5206513/ https://ncbi.nlm.nih.gov/pubmed/27965386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609375114 |
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