Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One main pathological feature of COPD is the loss of functional alveolar tissue without adequate repair (emphysema), yet the underlying mechanisms are poorly defined. Reduced WNT–β-catenin signaling is linked to impa...

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Udgivet i:J Exp Med
Main Authors: Baarsma, Hoeke A., Skronska-Wasek, Wioletta, Mutze, Kathrin, Ciolek, Florian, Wagner, Darcy E., John-Schuster, Gerrit, Heinzelmann, Katharina, Günther, Andreas, Bracke, Ken R., Dagouassat, Maylis, Boczkowski, Jorge, Brusselle, Guy G., Smits, Ron, Eickelberg, Oliver, Yildirim, Ali Ö., Königshoff, Melanie
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206496/
https://ncbi.nlm.nih.gov/pubmed/27979969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160675
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