Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One main pathological feature of COPD is the loss of functional alveolar tissue without adequate repair (emphysema), yet the underlying mechanisms are poorly defined. Reduced WNT–β-catenin signaling is linked to impa...

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Библиографические подробности
Опубликовано в: :J Exp Med
Главные авторы: Baarsma, Hoeke A., Skronska-Wasek, Wioletta, Mutze, Kathrin, Ciolek, Florian, Wagner, Darcy E., John-Schuster, Gerrit, Heinzelmann, Katharina, Günther, Andreas, Bracke, Ken R., Dagouassat, Maylis, Boczkowski, Jorge, Brusselle, Guy G., Smits, Ron, Eickelberg, Oliver, Yildirim, Ali Ö., Königshoff, Melanie
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2017
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206496/
https://ncbi.nlm.nih.gov/pubmed/27979969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160675
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