Niche WNT5A regulates the actin cytoskeleton during regeneration of hematopoietic stem cells

Here, we show that the Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs, which do not successfully engraft in secondary recipients. RNA sequencing of the regenerated donor Lin(−) SCA-1(+) KIT(+) (LSK) cells shows dysregulated expression of ZEB1-associated genes involved in the small GTPa...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Schreck, Christina, Istvánffy, Rouzanna, Ziegenhain, Christoph, Sippenauer, Theresa, Ruf, Franziska, Henkel, Lynette, Gärtner, Florian, Vieth, Beate, Florian, M. Carolina, Mende, Nicole, Taubenberger, Anna, Prendergast, Áine, Wagner, Alina, Pagel, Charlotta, Grziwok, Sandra, Götze, Katharina S., Guck, Jochen, Dean, Douglas C., Massberg, Steffen, Essers, Marieke, Waskow, Claudia, Geiger, Hartmut, Schiemann, Mathias, Peschel, Christian, Enard, Wolfgang, Oostendorp, Robert A.J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206491/
https://ncbi.nlm.nih.gov/pubmed/27998927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151414
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