Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway

Overcoming temozolomide (TMZ) resistance is a great challenge in glioblastoma (GBM) treatment. Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the biosynthesis of nicotinamide adenine dinucleotide and has a crucial role in cancer cell metabolism. In this study, we investi...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Feng, Jun, Yan, Peng-Fei, Zhao, Hong-yang, Zhang, Fang-Cheng, Zhao, Wo-Hua, Feng, Min
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206411/
https://ncbi.nlm.nih.gov/pubmed/28097126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1450843
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