Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing adjacent to each active site of a NAMPT homodim...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Tanuma, Sei-ichi, Katsuragi, Kiyotaka, Oyama, Takahiro, Yoshimori, Atsushi, Shibasaki, Yuri, Asawa, Yasunobu, Yamazaki, Hiroaki, Makino, Kosho, Okazawa, Miwa, Ogino, Yoko, Sakamoto, Yoshimi, Nomura, Miyuki, Sato, Akira, Abe, Hideaki, Nakamura, Hiroyuki, Takahashi, Hideyo, Tanuma, Nobuhiro, Uchiumi, Fumiaki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464552/
https://ncbi.nlm.nih.gov/pubmed/32785052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163633
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