Nur77 attenuates endothelin-1 expression via downregulation of NF-κB and p38 MAPK in A549 cells and in an ARDS rat model

Acute respiratory distress syndrome (ARDS) is characterized by inflammatory injury to the alveolar and capillary barriers that results in impaired gas exchange and severe acute respiratory failure. Nuclear orphan receptor Nur77 has emerged as a regulator of gene expression in inflammation, and its r...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Jiang, Yujie, Zeng, Yi, Huang, Xia, Qin, Yueqiu, Luo, Weigui, Xiang, Shulin, Sooranna, Suren R., Pinhu, Liao
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206403/
https://ncbi.nlm.nih.gov/pubmed/27765761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00043.2016
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