Na(+)-K(+)-Cl(−) cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal

Interstitial cells of Cajal (ICC) generate electrical slow waves by coordinated openings of ANO1 channels, a Ca(2+)-activated Cl(−) (CaCC) conductance. Efflux of Cl(−) during slow waves must be significant, as there is high current density during slow-wave currents and slow waves are of sufficient m...

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Zhu, Mei Hong, Sung, Tae Sik, Kurahashi, Masaaki, O'Kane, Lauren E., O'Driscoll, Kate, Koh, Sang Don, Sanders, Kenton M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
Matèries:
Neurogastroenterology and Motility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5206290/
https://ncbi.nlm.nih.gov/pubmed/27742704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00277.2016
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