Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families

MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA f...

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Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Wolter, Justin M., Le, Hoai Huang Thi, Linse, Alexander, Godlove, Victoria A., Nguyen, Thuy-Duyen, Kotagama, Kasuen, Lynch, Alissa, Rawls, Alan, Mangone, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204344/
https://ncbi.nlm.nih.gov/pubmed/27927717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.209361.116
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