Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families

MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well understood, nor is it clear what unique functions, if any, miRNA f...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Wolter, Justin M., Le, Hoai Huang Thi, Linse, Alexander, Godlove, Victoria A., Nguyen, Thuy-Duyen, Kotagama, Kasuen, Lynch, Alissa, Rawls, Alan, Mangone, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204344/
https://ncbi.nlm.nih.gov/pubmed/27927717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.209361.116
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