The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells

Cancer cells exhibit multiple epigenetic changes with prominent local DNA hypermethylation and widespread hypomethylation affecting large chromosomal domains. Epigenome studies often disregard the study of repeat elements owing to technical complexity and their undefined role in genome regulation. W...

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Udgivet i:Genome Res
Main Authors: Jordà, Mireia, Díez-Villanueva, Anna, Mallona, Izaskun, Martín, Berta, Lois, Sergi, Barrera, Víctor, Esteller, Manel, Vavouri, Tanya, Peinado, Miguel A.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5204336/
https://ncbi.nlm.nih.gov/pubmed/27999094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.207522.116
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