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β-Lactamases: A Focus on Current Challenges
β-Lactamases, the enzymes that hydrolyze β-lactam antibiotics, remain the greatest threat to the usage of these agents. In this review, the mechanism of hydrolysis is discussed for both those enzymes that use serine at the active site and those that require divalent zinc ions for hydrolysis. The β-l...
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| Udgivet i: | Cold Spring Harb Perspect Med |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5204326/ https://ncbi.nlm.nih.gov/pubmed/27742735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a025239 |
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